Here are the following differences between chemical reactions and nuclear reaction. 1. While nuclear reaction takes place in the atoms nucleus, the electrons in the atom are responsible for Chemical reactions. 2. The chemical reactions involve the transfer, loss, gain and sharing of electrons and nothing takes place in the nucleus. Nuclear reactions involve the decomposition of the nucleus and have nothing to do with the electrons. 3. In a nuclear reaction, the protons and neutrons react inside the nucleus and in chemical reactions the electrons react outside the nucleus. 4. When comparing the energies, a chemical reaction involves only low energy change, where as a nuclear reaction has a very high-energy change.