Pituitary Gland

Biology

definition

Hormones from anterior pituitary gland

Hormones from anterior pituitary gland are as follows:
  1. Growth hormones: Promote growth of whole body, particularly of the skeleton.
  2. Thyroid stimulating hormone: Stimulates thyroid to secrete thyroxine.
  3. Adrenocorticotropic hormone: Stimulate adrenal cortex.
  4. Gonadotrophic hormone: Regulates the activity of gonads (testes and ovaries).

definition

Pituitary gland- origin and location

The pituitary gland is a tiny organ present at the base of the brain. It is called the master gland of the body since it's secretions control hormone secretion from many glands in the body. 
Origin
Develops from the ectoderm layer of the embryo
Location
Located below the hypothalamus in a bony cavity called sella tursica (small depression in the sphenoid bone) 

definition

Hormones of the Pituitary gland (Anterior pituitary/Pars distalis)

The anterior pituitary gland (Adenohypophysis) secretes several important hormones. The various hormones and their functions are as follows
Growth hormone (GH)
  • Also called somatotropin
  • Promote growth of whole body, particularly of the skeleton.
Thyroid stimulating hormone (TSH)
  • Also called Thyrotropin 
  • Stimulates thyroid gland to secrete thyroxine.
Adrenocorticotrophic hormone (ACTH)
  • Also called corticotropin
  • Stimulate adrenal cortex to synthesize and secrete glucocorticoids
Follicle stimulating hormone (FSH)
  • FSH and LH together are called the gonadotropins
  • Stimulates egg formation in females and sperm formation in males.
Luteinizing hormone (LH)
  • Induces ovulation of the graffian follicles (fully mature follicles)
  • Maintains the corpus luteum formed after ovulation. 
  • It also stimulates the synthesis and secretion of androgens (hormones) from the testis
Prolactin
  • It promotes mammary gland development and milk production

definition

Hormones of the Pituitary gland (Pars intermedia)

Though the pars intermedia (of the adenohypophysis in the pituitary gland) of humans is almost fused with the pars distalis. It still secretes MSH hormone.
Melanocyte Stimulating Hormone (MSH)
  • Stimulates the synthesis of melanin pigment (the pigment responsible for the skin colour) in the melanocytes.
  • The hormone causes dispersal of melanin in chromatophores (present in melanocytes) causing darkening of the skin.

definition

Hormones of the Pituitary gland (Posterior pituitary/ Neurohypophysis)

The posterior pituitary gland/neurohypophysis does not synthesize any hormones. It contains the unmyelinated axons of the hypothalamus which secrete 2 hormones; The vasopressin and the oxytocin. These are stored in the neurohypophysis.
Vasopressin
  • Also called as Anti Diuretic Hormone (ADH) as it prevents diuresis (frequent urination)
  • It controls the water level in the body preventing the loss of water through urine.
  • It acts on the nephrons of the kidney and increases the reabsorption of water into the blood. ADH reduces urine volume 
  • It also causes vasoconstriction (constriction of blood vessels) hence the name vasopressin.
  • Both water reabsorption into the blood and vasoconstriction lead to increased blood pressure
Oxytocin
  • Stimulates uterine contraction during childbirth.
  • Stimulates the production of prostaglandins which increases the muscle contractions even more during childbirth.  
  • Stimulates ejection of milk from the breast during suckling.

definition

Pituitary gland- Detailed structure

The pituitary gland is the 'master gland' located at the base of the brain. It is attached to the hypothalamus with an infundibulum (stalk). The structure of pituitary can be anatomically divided into 2; Adenohypophysis and Neurohypophysis
Adenohypophysis
  1. It consists of 3 portions; pars distalis, pars intermedia and pars tuberalis.
  2. Pars distalis region of pituitary is referred to as anterior pituitary.
  3. Pars intermedia region is almost merged with pars distalis in humans.
  4. Pars tuberalis wraps the pituitary stalk with a sheath of cells.
  5. The anterior pituitary produces various hormones (e.g. Growth hormone)
Neurohypophysis
  1. It is also called pars nervosa/ posterior pituitary gland.
  2. A major portion of the posterior pituitary gland consists of unmyelinated axons from hypothalamic neurosecretory neurons.
  3. It stores the hormones (oxytocin and vasopressin) produced by the neurons of the hypothalamus.

definition

Hormones of the Pituitary gland

The anterior pituitary gland (Adenohypophysis), the pars intermedia and the posterior pituitary gland secrete several important hormones. The various hormones and their functions are as follows
Growth hormone (GH)
  • Also called somatotropin
  • Promote growth of whole body, particularly of the skeleton.
Thyroid stimulating hormone (TSH)
  • Also called Thyrotropin 
  • Stimulates thyroid gland to secrete thyroxine.
Adrenocorticotrophic hormone (ACTH)
  • Also called corticotropin
  • Stimulate adrenal cortex to synthesize and secrete glucocorticoids
Follicle stimulating hormone (FSH)
  • FSH and LH together are called the gonadotropins
  • Stimulates egg formation in females and sperm formation in males.
Luteinizing hormone (LH)
  • Induces ovulation of the graffian follicles (fully mature follicles)
  • Maintains the corpus luteum formed after ovulation. 
  • It also stimulates the synthesis and secretion of androgens (hormones) from the testis
Prolactin
  • It promotes mammary gland development and milk production
Melanocyte Stimulating Hormone (MSH)
  • Stimulates the synthesis of melanin pigment (the pigment responsible for the skin colour) in the melanocytes.
  • The hormone causes dispersal of melanin in chromatophores (present in melanocytes) causing darkening of the skin.
Vasopressin
  • Also called as Anti Diuretic Hormone (ADH) as it prevents diuresis (frequent urination)
  • It controls the water level in the body preventing the loss of water through urine.
  • It acts on the nephrons of the kidney and increases the reabsorption of water into the blood. ADH reduces urine volume 
  • It also causes vasoconstriction (constriction of blood vessels) hence the name vasopressin.
  • Both water reabsorption into the blood and vasoconstriction lead to increased blood pressure
Oxytocin
  • Stimulates uterine contraction during childbirth.
  • Stimulates the production of prostaglandins which increases the muscle contractions even more during childbirth.  
  • Stimulates ejection of milk from the breast during suckling.

definition

Pituitary gland

The anterior pituitary gland (Adenohypophysis), the pars intermedia and the posterior pituitary gland secrete several important hormones. The various hormones and their functions are as follows
Growth hormone (GH)
  • Also called somatotropin
  • Promote growth of whole body, particularly of the skeleton.
Thyroid stimulating hormone (TSH)
  • Also called Thyrotropin 
  • Stimulates thyroid gland to secrete thyroxine.
Adrenocorticotrophic hormone (ACTH)
  • Also called corticotropin
  • Stimulate adrenal cortex to synthesize and secrete glucocorticoids
Follicle stimulating hormone (FSH)
  • FSH and LH together are called the gonadotropins
  • Stimulates egg formation in females and sperm formation in males.
Luteinizing hormone (LH)
  • Induces ovulation of the graffian follicles (fully mature follicles)
  • Maintains the corpus luteum formed after ovulation. 
  • It also stimulates the synthesis and secretion of androgens (hormones) from the testis
Prolactin
  • It promotes mammary gland development and milk production
Melanocyte Stimulating Hormone (MSH)
  • Stimulates the synthesis of melanin pigment (the pigment responsible for the skin colour) in the melanocytes.
  • The hormone causes dispersal of melanin in chromatophores (present in melanocytes) causing darkening of the skin.
Vasopressin
  • Also called as Anti Diuretic Hormone (ADH) as it prevents diuresis (frequent urination)
  • It controls the water level in the body preventing the loss of water through urine.
  • It acts on the nephrons of the kidney and increases the reabsorption of water into the blood. ADH reduces urine volume 
  • It also causes vasoconstriction (constriction of blood vessels) hence the name vasopressin.
  • Both water reabsorption into the blood and vasoconstriction lead to increased blood pressure
Oxytocin
  • Stimulates uterine contraction during childbirth.
  • Stimulates the production of prostaglandins which increases the muscle contractions even more during childbirth.  
  • Stimulates ejection of milk from the breast during suckling.

definition

Pituitary disorders

The pituitary gland is the 'master control gland"  any changes in its normal functioning can affect various parts of the body. Some of the pituitary disorders include
  • Pituitary dwarfism
  • Gigantism
  • Acromegaly
  • Diabetes insipidus
  • Simmond's disease
  • High blood levels of ADH

definition

Disorders of the Pituitary gland- Pituitary Dwarfism

Dwarfism is a condition in which the growth of a person is very slow or delayed; as a result, they have smaller body size than the adults.
Causes
  • Pituitary dwarfism is a result of a deficiency of anterior pituitary secretion (panhypopituitarism) during childhood. 
  • Craniopharyngiomas (type of brain ) or chromophobe tumours compress and destroy the anterior pituitary gland 
  • Thrombosis (blood clot) in the pituitary blood vessels.
Symptoms
  • Though the body parts develop in appropriate proportion to one another there is decrease in the rate of development and the overall size of the body
  • Some people do not pass through puberty or develop adult sexual functions
  • If this condition arises in adults (with normal growth) then they have complications like lethargy, hypothyroidism, decreased gonadotropins leading to loss of sexual functions.

definition

Disorders of Pituitary gland- Gigantism

Excess production of growth hormone (in pre-adolescence) can lead to a condition called gigantism in which all body tissues grow rapidly including the bones.
If the condition occurs in adolescence before the bones are completely grown (i.e. before the epiphyses of the long bones have become fused with the shafts) the person grows to be a giant (up to 8 feet tall).
Causes
  • Excess secretion of growth hormone from the pituitary.
  • usually because of  a tumour of the pituitary gland that grows until the gland itself is destroyed
Symptoms
  • Giant body
  • Hyperglycemia (increased blood glucose levels)
  • Some of them develop diabetes mellitus

definition

Disorders of Pituitary gland- Acromegaly

Acromegaly is a condition in which there is enlargement of certain bones like; the bones of the hands and feet, the cranium, forehead, nose, lower jawbone, and portions of the vertebrae. 
They are enlarged because their growth does not stop at adolescence.
Causes
  • Excess production of growth hormone from the pituitary after adolescence i.e. after the bones are completely grown (i.e. before the epiphyses of the long bones have become fused with the shafts)
    Usually because of a pituitary tumour
  • Usually because of a pituitary tumour
Symptoms
  • Enlarged bones
  • Kyphosis (hunched back, because of enlargement of vertebrae)
  • Enlargement of organs like tongue, liver and kidneys

definition

Disorders of Pituitary gland- Diabetes insipidus

Diabetes insipidus is a condition which results in the formation of a large volume of dilute urine (close to 15 Liters/day).
It is of two types; central diabetes insipidus and nephrogenic diabetes insipidus.
Causes
  • Central diabetes insipidus is due to inability of the posterior pituitary to produce or release enough vasopressin or Anti-Diuretic hormone (Diuresis- formation of excess urine)
  • Common causes include; Injury to pituitary or hypothalamus or head, surgery, a tumour, an illness (such as meningitis).
Symptoms
  • Extreme thirst
  • Excessive urination
  • Severe dehydration

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Hypothalamus

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Parathyroid Glands

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Testes and Ovaries

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Thymus Gland

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