Pancreas

Biology

definition

Pancreas (islets of Langerhans)

  • Pancreas produce insulin from beta cells, glucagon from alpha cells and somatostatin from delta cells of Islets of Langerhans.

definition

Extrenal structure of pancreas

  • The pancreas comprises of head, neck, body and tail.
  • The main pancreatic duct is formed from smaller ducts within the pancreas, which opens into hepatopancreatic ampulla.
  • An accessory duct is also present in pancreas which opens directly into the duodenum.

definition

Function of hormones secreted by pancreas

The three main hormones produced by the endocrine pancreas and their functions are
Glucagon
  • It is a polypeptide hormone.
  • It is secreted by the pancreas when the glucose level in the blood drops.
  • It increases the blood glucose levels by initiating glycogenolysis (glycogen degradation) and stimulating gluconeogenesis (synthesis of glucose from non-carbohydrate molecules) in the liver cells.
  • Since it increases the blood glucose levels it is a hyperglycemic (hyper-more, glycemic-sugar levels) hormone
  • It also initiates lipolysis (degradation of lipid) in the adipose tissue.
Insulin
  • It is also a polypeptide hormone
  • It has antagonistic (opposite) effects of the hormone glucagon.
  • It is released when the glucose level in the blood raises.
  • It lowers blood sugar levels in different ways; increasing the uptake of glucose by all the cells in the body, initiating glycogenesis (glycogen synthesis) in the liver and muscle.
  • It initiates lipogenesis (synthesis of lipids/fat) and storage of fat in adipose tissue and inhibits gluconeogenesis
  • It is a hypoglycemic (hypo=less) hormone as it reduces the sugar levels in the blood
Somatostatin
  • Also known as growth hormone-inhibiting hormone (GHIH)
  • It acts locally on the Islets of Langerhans and inhibit the secretion of both insulin and glucagon
  • It also reduces gastric secretions and inhibits the release of gastrointestinal hormones
Pancreatic Polypeptide
  • It is a polypeptide secreted by the  cells of the pancreas.
  • Protein is strong stimulus for its production
  • It affects gastric and biliary secretion and motility of the GI tract

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