The thyroid gland is an endocrine gland in the neck. Origin
Develops from the endoderm of the embryo
Location
It is located at the base of the neck just below Adam's apple. Anterior to the thyroid cartilage of the larynx in the neck.
Structure
It is butterfly shaped, bilobed organ.
The two lobes are interconnected with a tissue called isthmus.
It contains 2 types of tissues; Follicles and stromal tissues
Follicles are made of follicular cells which synthesize the thyroid hormones
The stromal tissue forms the connective tissue that supports the follicular cells.
definition
Thyrocalcitonin
Thyrocalcitonin is a hormone secreted by thyroid gland that plays an important role in the calcium metabolism
It is polypeptide hormone secreted by the 'C' cells of the thyroid gland.
It is secreted when calcium level is high in the blood.
It reduces the calcium levels in the blood by promoting bone formation by the osteoblasts and by inhibiting renal tubular reabsorption of calcium
It has the antagonistic effect of parathyroid hormone
definition
Hypothyroidism
A condition in which the thyroid gland doesn't produce enough thyroid hormone (thyroxine). Causes
They are many disorders that cause hypothyroidism; autoimmune disorders (e.g. Hashimoto's disease - autoantibodies against thyroid), iodine deficiency, pituitary disease, certain medications etc.
Symptoms
Fatigue
Depression
Memory loss
Dry and rough skin
Joint and muscle pain
Weight gain and
inability to tolerate pain
definition
Hyperthyroidism
Hyperthyroidism is a disorder in which your thyroid gland makes and releases more thyroid hormone than the body needs. Causes
Graves' disease
Thyroid adenoma (tumor in thyroid gland)
Toxic goiter [different from endemic colloid goiter caused by dietary Iodide deficiency (hypothyroidism)]
Symptoms
Increased sweating
mild to extreme weight loss
Muscle weakness
Exophthalmos - protrusion of eyeballs (due to swelling of the ocular/eye muscles )
High state of excitability (quick reactions)
intolerance to heat
Tremors of the hands
Diarrhea
Nervous disorders
Extreme fatigue
Inability to sleep
definition
Disorders of thyroid gland- Hyperthyroidism- Graves' disease
Graves' disease is the most common reason for hyperthyroidism.
It is an autoimmune disorder.
Antibodies are generated against Thyrotropin stimulating receptor (TSH/thyrotropin receptor) in the thyroid gland
These antibodies called the thyroid-stimulating immunoglobulins (TSIs) bind to the TSH receptor
TSIs binding to the TSH receptor (the receptors that were supposed to bind TSH) leads to the continuous production of thyroid hormone by the thyroid gland.
Excess production of thyroid hormone leads to hyperthyroidism.