Thyroid Gland

Biology

definition

Function of thyroid gland

  • Regulates the basal metabolism.
  • Promotes movement of calcium ions from blood to bones.

definition

Thyroid gland

Thyroid produces thyroxine which regulates metabolism.
  • Hypothyroidism: Undersecretion of thyroxine causes simple goitre, cretinism and myxoedema.
  • Hyperthyroidism: Oversecretion produces exophthalmic goitre.

definition

Thyroid gland- Origin, location and structure

The thyroid gland is an endocrine gland in the neck. 
Origin
  • Develops from the endoderm of the embryo
Location
  • It is located at the base of the neck just below Adam's apple. Anterior to the thyroid cartilage of the larynx in the neck.
Structure
  • It is butterfly shaped, bilobed organ.
  • The two lobes are interconnected with a tissue called isthmus.
  • It contains 2 types of tissues; Follicles and stromal tissues
  • Follicles are made of follicular cells which synthesize the thyroid hormones
  • The stromal tissue forms the connective tissue that supports the follicular cells.

definition

Thyrocalcitonin

Thyrocalcitonin is a hormone secreted by thyroid gland that plays an important role in the calcium metabolism
  • It is polypeptide hormone secreted by the 'C' cells of the thyroid gland. 
  • It is secreted when calcium level is high in the blood.
  • It reduces the calcium levels in the blood by promoting bone formation by the osteoblasts and by inhibiting renal tubular reabsorption of calcium 
  • It has the antagonistic effect of parathyroid hormone

definition

Hypothyroidism

A condition in which the thyroid gland doesn't produce enough thyroid hormone (thyroxine).
Causes
  • They are many disorders that cause hypothyroidism; autoimmune disorders (e.g. Hashimoto's disease - autoantibodies against thyroid), iodine deficiency, pituitary disease, certain medications etc. 
Symptoms
  • Fatigue
  • Depression
  • Memory loss
  • Dry and rough skin
  • Joint and muscle pain
  • Weight gain and 
  • inability to tolerate pain

definition

Hyperthyroidism

Hyperthyroidism is a disorder in which your thyroid gland makes and releases more thyroid hormone than the body needs.
Causes 
  • Graves' disease
  • Thyroid adenoma (tumor in thyroid gland)
  • Toxic goiter [different from endemic colloid goiter caused by dietary Iodide deficiency (hypothyroidism)]
Symptoms 
  • Increased sweating
  • mild to extreme weight loss
  • Muscle weakness
  • Exophthalmos - protrusion of eyeballs (due to swelling of the ocular/eye muscles )
  • High state of excitability (quick reactions)
  • intolerance to heat
  • Tremors of the hands
  • Diarrhea
  • Nervous disorders
  • Extreme fatigue
  • Inability to sleep

definition

Disorders of thyroid gland- Hyperthyroidism- Graves' disease

Graves' disease is the most common reason for hyperthyroidism. 
  • It is an autoimmune disorder.
  • Antibodies are generated against Thyrotropin stimulating receptor (TSH/thyrotropin receptor) in the thyroid gland
  • These antibodies called the thyroid-stimulating immunoglobulins (TSIs) bind to the TSH receptor
  • TSIs binding to the TSH receptor (the receptors that were supposed to bind TSH) leads to the continuous production of thyroid hormone by the thyroid gland.
  • Excess production of thyroid hormone leads to hyperthyroidism.

REVISE WITH CONCEPTS

Hypothalamus

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Pituitary Gland

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Adrenal Glands

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Pineal Gland

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Pancreas

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Parathyroid Glands

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Testes and Ovaries

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Thymus Gland

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