Intracellular acidosis due mainly to lactic acid accumulation has been regarded as the most important cause of skeletal muscle fatigue. Inorganic phosphate, which increases during fatigue due to the breakdown of creatine phosphate appears to be a major cause of muscle fatigue.
So, the correct option is 'Lactic acid'.
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The main cause for muscle fatigue
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Lactic acid causes fatigue in muscles due to
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How does lactic acid accumulation cause muscle fatigue?
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Name the chemical that causes fatigue in the muscle