The smooth endoplasmic reticulum packages proteins for transport, synthesizes membrane phosolipids, and releases calcium. Other functions of the smooth endoplasmic reticulum include transformation of bile pigments, glycogenolysis (the breakdown of glycogen), and detoxification of many drugs and chemical agents. The smooth endoplasmic reticulum is another organelle in eukaryotic cells that synthesizes lipids. This organelle is located near the rough endoplasmic reticulum, and it produces phospholipids and cholesterol that help stabilize the membranes of the entire cell. The ribosomes in the rough endoplasmic reticulum manufacture proteins. These proteins are manufactured from chains of amino acids.