Question

According to the accepted concept of hormone action, if receptor molecules are removed from target organs

• A. The target organ will continue to respond to the hormone without any difference.
• B. The target organ will continue to respond to the hormone but will require higher concentration.
• C. The target organs will not respond to the hormone.
• D. The target organ will continue to respond to the hormone but in the opposite way.

Answer 1

Answer: (C)

The correct option is C The target organs will not respond to the hormone.
Though hormones are released into the blood stream and hence can reach all cells, yet they affect only those cells which have hormone specific receptors. Thus, binding of hormone to receptor is crucial irrespective of presence of receptors inside the cell or on its surface. This makes options A and D incorrect as absence of receptors renders the cell unaffected by hormonal action. Option B is incorrect as hormone-receptor binding is essential step in hormonal action. Thus, in absence of receptors, the target organ will no longer respond to hormone. Option C is correct.