If a person sits at a place for a longer period of time or remains inactive, then he can be obese and have diabetes.
Option A - 'Detestable' means deserving intense dislike. Thus option A is incorrect.
Option B - 'Hard' means difficult. Thus option B is incorrect.
Option C - 'Irregular' means uneven or not regular. Thus option C is incorrect.
Option D - 'Sedentary' means tending to spend much time seated or to be inactive. Thus option D is incorrect.
'The job made him obese and led to diabetes.'