Adrenocorticotropic hormone (ACTH) is secreted by anterior pituitary which targets the adrenal cortex to stimulate secretion of corticoids and sex hormones. Excessive ACTH secretion results in hyperproduction of adrenal cortex hormones. Excess cortisol causes deposition of subcutaneous fat and stimulated muscle protein metabolism and finally leads to diabetes mellitus. This makes option A incorrect as Cushing disease’s symptoms includes increased protein metabolism, obese trunk with normal arms and legs, stimulated reabsorption of water and sodium making the blood pH basic and causing hypertension also. Option C is incorrect as undersecretion of insulin causes diabetes mellitus type I which is characterized by acidic pH, increased fat metabolism and formation of ketone bodies. Correct answer is B.