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Question

During synaptic transmission of nerve impulse, neurotransmitter (P) is released from synaptic vesicles by the action of ions (Q). Choose the correct P and Q.
  1. P = acetylcholine, Q = Ca++
  2. P = acetylcholine, Q = Na++
  3. P = GABA, Q = Na+
  4. P = Cholinesterase, Q = Ca++.

A
P = Cholinesterase, Q = Ca++.
B
P = acetylcholine, Q = Ca++
C
P = acetylcholine, Q = Na++
D
P = GABA, Q = Na+
Solution
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The correct option is A P = acetylcholine, Q = Ca++
Acetylcholine is stored in tiny membrane ‘packets’ called synaptic vesicles which can be triggered to secrete by fusing with the presynaptic membrane at the ‘transmitter release site’. The synaptic vesicles are docked at the release site ready for secretion. Influx of calcium ions through selective voltage‐sensitive ion channels (calcium channels) play a key role to link the action potential to the triggering of secretory vesicle discharge. Calcium channels are positioned very close to the secretory vesicles so that when they open the spurt of entering calcium ions, called a ‘calcium domain’, can rapidly and effectively access the triggering sites for synaptic vesicle fusion.
So, the correct answer is option A.

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