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Question

Given the fact that histone binds DNA, it should be rich in.
  1. Arginine, lysine
  2. Cysteine, methionine
  3. Glutamate, aspartate
  4. Isoleucine, leucine

A
Cysteine, methionine
B
Arginine, lysine
C
Isoleucine, leucine
D
Glutamate, aspartate
Solution
Verified by Toppr

  • The DNA is wound around an octamer of histone core proteins giving rise to a bead-like structure called nucleosomes.
  • The histone proteins contain a high percentage of basic amino acids such as lysine and arginine that confer a positive charge on the proteins.
  • The positive charge of histone proteins helps in the coiling of negatively charged DNA around them.
Thus the correct answer is option A.

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