Question

# One picogram (pg) is equal to how many base pairs (bp)?

A
1×109
B
0.965×109
C
0.965×1010
D
0.963×108
Solution
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#### The weight of nucleotide bases can be calculated from the chemical formula and relative weights can be used to correlate the weight with the number of bases expected in a given sample of DNA. Using this technique it has been estimated that the mean weight of one nucleotide pair would be 1.023 x 109 pg, and 1 pg of DNA would represent 978000000 base pairs. Some workers have reported a lower value (965000000). The correct formula for converting the picograms of DNA into number of nucleotide pairs will be (978000000) x (DNA content in picograms).Thus, the correct answer is option B.

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