Osteoporosis- an age-related disease of skeleton system- may occur due toDecreased level of estrogenAccumulation of uric acid leading to inflammation of jointsImmune disorder affecting neuro-muscular junction leading to fatigueHigh concentration of Ca- and Na-

Question

Toppr Admin · Accepted Answer

Estrogen regulates osteoblast activity and stimulate bone formation. Menopause leads to lower estrogen level causing lower/no osteoblast activity. The overall effect is lower bone mass and thinning of bones which are more prone to fractures. Accumulation of uric acid leading to inflammation of joints leads to gout. Myasthenia gravis is immune disorder of neuromuscular junction that causes weakening of muscles.
Therefore, the correct answer is option A.

Column -I	Column-II
(a)	Gout	(i)	Decreased levels of estrogen
(b)	Osteoporosis	(ii)	Low $C a^{+ +}$ ions in the blood
(c)	Tetany	(iii)	Accumulation of uric acid crystals
(d)	Muscular dystrophy	(iv)	Auto immune disorder
		(v)	Genetic disorder

Osteoporosis, an age-related disease of skeleton system, may occur due toDecreased level of estrogenAccumulation of uric acid leading to inflammation of jointsImmune disorder affecting neuro-muscular junction leading to fatigueHigh concentration of Ca++ and Na+

Osteoporosis, an age-related disease of skeleton system, may occur due to
Decreased level of estrogen
Accumulation of uric acid leading to inflammation of joints
Immune disorder affecting neuro-muscular junction leading to fatigue
High concentration of Ca $^{+ +}$ and Na $^{+}$