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Question

Poisonous substance released on rupturing of schizont of RBC in a patient of malaria is
  1. Haemoglobin
  2. Haemozoin
  3. Haematin
  4. Haem

A
Haemoglobin
B
Haemozoin
C
Haematin
D
Haem
Solution
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Haemozoin is a disposal product formed from the digestion of blood by some blood-feeding parasites. These organisms such as malaria parasites (Plasmodium spp.) digest haemoglobin and release high quantities of free haeme, which is the non-protein component of haemoglobin. A haeme is a prosthetic group that consists of an iron atom contained in the center of a heterocyclic porphyrin ring. Free haeme is toxic to cells, so the parasites convert it into an insoluble crystalline form called haemozoin. In malaria parasites, haemozoin is often called malaria pigment.

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