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Question

The gene disorder phenyl ketonuria is an example for ___________.
  1. Polygenic inheritance
  2. Pleiotropy
  3. Multiple allelism
  4. Multiple factor.

A
Multiple factor.
B
Multiple allelism
C
Polygenic inheritance
D
Pleiotropy
Solution
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The correct option is B Pleiotropy

Phenylketonuria is a recessive autosomal disorder related to phenylalanine metabolism. It is controlled by a single gene having multiple phenotypes. So it is a pleiotrophy. This disorder is due to the absence of a liver enzyme phenylalanine hydroxylase. Due to the lack of this enzyme, phenylalanine follows another pathway and gets converted into phenyl pyruvic acid. This phenyl pyruvic acid upon accumulation in joints causes arthritis. If it hits the brain, it causes mental retardation known as phenyl pyruvic idiocy.

So, the correct option is ‘Pleiotrophy’

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