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Question

What is the order of the decreasing reactivity for the carboxylic acid derivatives given above, in a nucleophilic substitution reaction?
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  1. II, IV, I, III
  2. I, II, III, IV
  3. IV, I, II, III
  4. III, IV, I, II

A
III, IV, I, II
B
IV, I, II, III
C
II, IV, I, III
D
I, II, III, IV
Solution
Verified by Toppr

Acid chloride is the most reactive followed by acid anhydride, then ester and amide is the most stable acid derivative. So, the order is as given above :

Hence, the correct option is A.

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