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Question

Which antibiotic inhibits interaction between tRNA and mRNA during bacterial protein synthesis?
  1. Tetracycline
  2. Erythromycin
  3. Neomycin
  4. Streptomycin

A
Tetracycline
B
Erythromycin
C
Neomycin
D
Streptomycin
Solution
Verified by Toppr

The correct option is C Neomycin
  • Neomycin is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of target bacteria. This binding interferes with mRNA binding with the tRNA sites. This results in the production of nonfunctional or toxic peptides.
  • Erythromycin binds to 50S subunit and inhibits translocation of the subunit during translation.Streptomycin bind to 30S subunit and causes the misreading of genetic code that leads to abnormal proteins.
  • Tetracycline binds to the 30S subunit and blocks addition of amino acids producing incomplete and probably non-functional proteins

So, the correct answer is 'Neomycin'

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Q1
Which antibiotic inhibits interaction between tRNA and mRNA during bacterial protein synthesis?
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Antibiotic inhibiting interaction between tRNA and mRNA during protein synthesis in bacteria is
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Q3
Some of the inhibitors of bacterial protein synthesis and their effect are listed below. Match them and choose the correct option from the answer key.

List I List II
AChloramphenicolpInhibits binding of aminoacyl tRNA to ribosome
BErythromycin
qInhibits interaction between tRNA and mRNA
CNeomycin
rInhibits initiation of translation
DStreptomycin
sInhibits peptidyl transferase activity
ETetracycline
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Match the columns and bring out the correct option of inhibitor and its effect
Column IColumn II
(a)Chloramphenicol(p)Inhibits binding of aatRNA to ribosome
(b)Erthromycin(q)Inhibits interaction between tRNA and mRNA
(c)Neomycin(r)Inhibits initiation of translation
(d)Streptomycin(s)Inhibits peptidyl transferase activity
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Some of the inhibitors of bacterial protein synthesis and their effect are listed in Column I and Column II below. Match and choose the correct option from answer key:
Column IColumn II(a)Chloramphenicol(p)Inhibits binding of aminoacyl tRNA to ribosome(b)Erythromycin(q)Inhibits interaction between tRNA and mRNA(c)Neomycin(r)Inhibits initiation of translation(d)Streptomycin(s)Inhibits peptidyl transferase activity(e)Tetracycline(t)Inhibits translocation of mRNA along ribosomes
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