Question

Which of the following is the least likely to be involved in stabilizing the three-dimensional folding of most proteins?

• A. Hydrogen bonds
• B. Ester bonds
• C. Hydrophobic interaction
• D. Electrostatic interaction

Answer 1

Answer: (B)

Three-dimensional folding of proteins refers to bringing the amino acids that are located far apart in the polypeptide sequence together within the completely folded structure of a protein. Different types of weak interaction hold the interacting segments together in protein. Hydrophobic interaction, H bonds and electrostatic interactions are the weak ones and stabilize the tertiary structure of proteins while ester bonds are covalent bonds and are least likely to be found therein.

Therefore, the correct answer is option B.