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Question

Which of the following most appropriately describes haemophilia?
  1. X - linked recessive gene disorder
  2. Recessive gene disorder
  3. Chromosomal disorder
  4. Dominant gene disorder

A
Recessive gene disorder
B
Dominant gene disorder
C
Chromosomal disorder
D
X - linked recessive gene disorder
Solution
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Haemophilia is a sex-linked recessive disorder. These kinds of defects occur more often in men than in women. A daughter gets an X chromosome from her mother and an X chromosome from her father. If, the X chromosome from her mother has the gene for normal blood clotting and the X chromosome from father has the gene for haemophilia. The daughter will not have haemophilia since the normal blood clotting gene from her mother is dominant. It won't allow the instructions from the haemophilia gene to be sent. The daughter is called a carrier for haemophilia. She has the gene on one of her X chromosomes and could pass it on to her children.
So, the correct answer is option B.

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Q1
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(i) Haemophilia is a sex-linked recessive disease.
(ii) Down's syndrome is due to aneuploidy.
(iii) Phenylketonuria is an autosomal dominant gene disorder.
(iv) Phenylketonuria is an autosomal recessive gene disorder.
(v) Sickle-cell anaemia is an X-linked recessive gene disorder.

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Q2
A male carrying a faulty gene for an X-linked recessive disorder will always be affected.
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Q3
Pick out the correct statements (a) Haemophilia is a sex-linked recessive disease (b) Down syndrome is due to aneuploidy (c) Phenylketonuria is an autosomal recessive gene disorder (d) Sickle cell anaemia is X-linked recessive gene disorder.
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Q4
Pick out the correct statements.

I. Haemophilia is a sex linked recessive disease.
II. Inheritance pattern of haemophilia is the same as that of color blindness.
III. Phenylketonuria is an autosomal recessive gene disorder.
IV. Sickle cell anaemia is an X-linked recessive gene disorder.

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Q5
X-linked recessive genes can be easily expressed in which of the following?
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