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Question

Which one of the following is not a second messenger in hormone action?
  1. Sodium
  2. cAMP
  3. cGMP
  4. Calcium

A
cAMP
B
Calcium
C
cGMP
D
Sodium
Solution
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Second messengers are the low molecular weight molecules that serve to transmit and amplify the signal of hormones.They can be hydrophobic, hydrophilic or gaseous molecules. Calcium serves as the secondary messenger for group II C hormones. cAMP serves as the secondary messenger for group II A hormones while cGMP serves as the secondary messenger for group II B hormones. Sodium does not serve as the secondary messenger for any hormone. So, the correct answer is A
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