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Difference Between Smooth Endoplasmic Reticulum And Rough Endoplasmic Reticulum

The main difference between these two terminologies is that the Smooth Endoplasmic Reticulum is known for stocking the lipids and proteins. It is not bounded by ribosomes. Whereas, the Rough Endoplasmic Reticulum is bounded by the ribosomes and also stores proteins. Learn the difference between smooth endoplasmic reticulum and rough endoplasmic reticulum.

Difference Between Smooth Endoplasmic Reticulum And Rough Endoplasmic Reticulum

Let us unfold more key points that exhibit the difference between the smooth endoplasmic reticulum and rough endoplasmic reticulum.

difference between smooth endoplasmic reticulum and rough endoplasmic reticulumdifference between smooth endoplasmic reticulum and rough endoplasmic reticulum

Character Smooth Endoplasmic Reticulum (SER) Rough Endoplasmic Reticulum (RER)
Definition Smooth Endoplasmic Reticulum does not have ribosomes on its membrane. Rough Endoplasmic Reticulum possesses ribosomes attached to its membrane.
Organized It is organized of vesicles and tubules. It is organized of cisternae and a few tubules.
Found  It is present near the cell membrane. It is present near the cytoplasm.
Formation SER gives rise to Spherosomes/ Oleosomes. RER helps in the formation of lysosomes.
Composed of It is composed of the tubules. It is composed of the cisternae.
Synthesis Synthesises glycogen, lipids, and steroids. It participates in the synthesis of enzymes and proteins.
Connection SER may be connected to plasmalemma and is peripheral. RER is connected with the nuclear envelope and is internal.
Development Develops from Rough Endoplasmic Reticulum. It might develop from the nuclear envelope.
Ribophorins It lacks in Ribophorins. It consists of ribophorins and helps ribosomes attach to ER
Provide Provides vesicles for cis-face of the Golgi apparatus. Provides proteins and lipids for the Golgi apparatus.
Produces It produces lipids and proteins. It produces proteins.

Smooth Endoplasmic Reticulum

Smooth Endoplasmic Reticulum or SER appears to be like a smooth surface when viewed from the electron microscope as they do not contain ribosomes. They are also known as Agranular Endoplasmic Reticulum. The SER plays a vital role in the production, storage, and secretion of the steroid hormones and lipids. It also helps in the manufacturing process of new membranes and the metabolism of carbohydrates.

In the cells of mammal, SER plays a vital role to detoxify the reactions of drugs and other metabolic wastes. In liver cells, it provides the enzyme glucose-6-phosphate, which conscientiously takes part in the metabolism. SER is organized from the Rough ER when there is a mislaying of the ribosomes. It helps in the transportation of the protein but does not take part in protein synthesis.

Rough Endoplasmic Reticulum

Rough Endoplasmic Reticulum or RER looks like an uneven surface because of the presence of the 80S ribosomes, when viewed in the electron microscope. It is also known as the Granular Endoplasmic Reticulum.

The main function of the RER is to take part in the protein synthesis and helps in the transportation of the protein to other parts. It plays an important role to manufacture, sort (pack), and transport the secretory proteins like antibodies, insulin, blood clotting proteins, enzymes, collagen, mucin, etc in cells like fibroblast, goblet cells, hepatic cells, pancreatic cells, and B lymphocytes.

Key Differences Between Smooth and Rough Endoplasmic Reticulum

The appearance of Smooth ER is like it contains many circular marks. These marks are the interlocking tubular sheets, whereas the Rough ER appears like the organization of the double membranes which are spotted with the ribosomes all over. RER consists of the parallel sheets of the membrane.

Smooth ER is located near the cell membrane while Rough ER is present near the cytoplasm of the eukaryotic cells.

Smooth ER is derived from rough endoplasmic reticulum by sacrificing the ribosomes, whereas Rough ER originates from the nuclear membrane.

The main difference between the SER and RER is the presence of ribosomes, as SER does not consist of ribosomes but RER consists of ribosomes.

SER mainly manufactures and transports the lipids and protein and it helps in detoxification, whereas RER helps in the production, secretion, and transportation of the proteins and few hormones.


This article concludes that we studied the important part and functions of the plant and animal cells, along with how they vary from each other. So, the Endoplasmic Reticulum whether smooth or rough has significant roles in the production and processing of various molecules.

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