Understanding the difference between nucleotide and nucleoside is a necessity in the field of science. Simply speaking, a nucleotide consists of sugar, a nitrogenous base, and phosphate groups that number one to three. In contrast, a nucleoside involves a nitrogenous base that has a covalent attachment to sugar but with no phosphate group.
Definition of Nucleotide
A nucleotide refers to the basic building block of a specific acid that is the nucleic acid. This certainly shows the difference between nucleotide and nucleic acid. Moreover, a nucleotide involves a sugar molecule whose attachment is to a phosphate group as well as a nitrogen-containing base.
Definition of Nucleoside
Nucleoside refers to a component of nucleotide and this is the difference between nucleotide and nucleoside. Furthermore, nucleotide happens to be the monomeric unit of nucleic acid, which is the DNA and RNA. Moreover, a nucleobase is a nitrogen-containing compound that may cause the formation of nucleosides when their attachment takes place to deoxyribose or a five-carbon sugar ribose.
Difference between Nucleotide and Nucleoside
|Structure||It consists of a nitrogenous base, one to three phosphate groups, and sugar-like deoxyribose and ribose||It consists of a nitrogenous base that has an attachment to sugar in a covalent manner without the phosphate group|
|Medical Relevance||Nucleotides that are dysfunctional lead to the onset of cancer due to the accumulation of damaged DNA||Use of several nucleoside analogues takes place in medicine as anticancer agents or antiviral|
|Composition||It consists of nucleoside in addition to one or more phosphate groups||It consists of a nitrogenous base in addition to Pentose sugar|
|Role in Nucleic Acids||It makes covalent bonds with other nucleotides to result in the formation of nucleic acid strand||It undergoes phosphorylation to result in the formation of nucleotides|
|Examples||Uridine monophosphate, guanosine monophosphate, cytidine monophosphate, adenosine monophosphate, thymidine monophosphate||Uridine, guanosine, cytidine, adenosine, thymidine|
More Details about Nucleotide
A nucleotide refers to an organic molecule that happens to be the building block of RNA and DNA. Furthermore, nucleotides have functions that have a relation to enzyme reactions, cell signaling, and metabolism. Also, the nucleotide is of three parts: a phosphate group, a nitrogenous base, and a 5-carbon sugar.
The four nitrogenous bases in DNA are guanine, cytosine, adenine, and thymine. Furthermore, a nucleotide within a particular chain forms the genetic material of every organism. They also serve many functions as energy moving particles and messengers outside the genetic information storage.
There is a difference between DNA and RNA as DNA has sugar deoxyribose while RNA has sugar ribose. Furthermore, codon refers to a series of three nucleotides within the DNA. Moreover, codon directs the cell proteins to attach a particular protein to a DNA specified series.
More Details about Nucleoside
A nucleoside refers to a purine or a pyrimidine nucleobase that is bound to a deoxyribose or pentose sugar ribose. Furthermore, in a nucleoside, there is an attachment of anomeric carbon to a purine’s N9 by a glycosidic bond. Furthermore, this attachment can also be to the N1 of a pyrimidine rather than the N9 of purine.
There is a difference between purine and pyrimidine. Purine has a six-membered nitrogen-containing ring in fusion to an imidazole ring. In contrast, pyrimidine has only the nitrogen-containing ring that is six-numbered.
On the basis of the pentose sugar component, it is possible for a nucleoside to be either a ribonucleoside or a deoxyribonucleoside. A ribonucleoside is simply a nucleoside with the component of the ribose sugar. In contrast, deoxyribonucleoside happens to be a nucleoside with a deoxyribose sugar.
FAQs about Nucleotide and Nucleoside
Question 1: State one difference between nucleotide and nucleoside?
Answer 1: One difference between nucleotide and nucleoside can be on the basis of chemical composition. A nucleotide consists of nucleoside in addition to phosphate groups that number one or more. In contrast, nucleoside consists of a nitrogenous base with the notable addition of Pentose sugar.
Question 2: Explain the difference between purine and pyrimidine?
Answer 2: Besides the difference between nucleotide and nucleoside, there is also a difference between purine and pyrimidine. Purine has a six-membered nitrogen-containing ring which is in fusion to an imidazole ring. In contrast, pyrimidine has only the nitrogen-containing ring that is six-numbered without any fusion.